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Polyphasic linkage and the impact of ligand binding on the regulation of biomolecular condensates.

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  • UserDr Kiersten Ruff, Washington University in St. Louis
  • ClockMonday 16 May 2022, 14:00-14:30
  • HouseVenue to be confirmed.

If you have a question about this talk, please contact Jerelle Joseph.

Cellular matter can be spatially and temporally organized via the formation of membraneless biomolecular condensates. Intermolecular interactions among multivalent molecules, known as scaffolds, lead to phase separation and the formation of biomolecular condensates. Scaffold-driven phase separation can be regulated by titrating the concentration of regulatory molecules, which we refer to as ligands. Polyphasic linkage, introduced by Wyman and Gill, describes the linkage between ligand binding and the modulation of scaffold phase behavior. Using the framework of polyphasic linkage we utilize a stickers-and-spacers model to uncover features of ligands that promote or suppress scaffold-driven phase separation. Our work also highlights how measuring dilute phase concentrations of scaffolds will be important for understanding the effects of ligands in cells. Overall, insights gained from the application of polyphasic linkage concepts should be useful for understanding biological and pharmaceutical regulation of condensates in vivo.

This talk is part of the Lennard-Jones Centre series.

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