University of Cambridge > > Morphogenesis Seminar Series > Composite morphogenesis: how can a tissue fold and extend at the same time

Composite morphogenesis: how can a tissue fold and extend at the same time

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  • UserMatteo Rauzi (IBV, Nice)
  • ClockMonday 25 April 2022, 14:30-15:30
  • HouseOnline.

If you have a question about this talk, please contact Elena Scarpa.

During embryo development, epithelia can undergo different shape transformations. While these changes can be sequential, and thus driven by specific sequential cellular mechanisms, this is not always the case. A single tissue can undergo multiple simultaneous shape transformations resulting in a composite process. For instance, in vertebrates, during neurulation, the dorsal tissue folds forming the neural tube while elongating along the anterior-posterior axis separating the future head from the anus (Keller, 2002). This raises an important question: how can a tissue undergo multiple simultaneous shape transformations if each transformation is per se driven by different and functionally specific cellular mechanisms? In addition, which signaling pathways are controlling composite morphogenetic processes? We use the early gastrulating Drosophila embryo as model system and focus on the process of mesoderm invagination during which the tissue on the ventral side of the embryo simultaneously folds and extends. By using advanced multi-view light sheet microscopy coupled to infrared femtosecond laser manipulation, optogenetics and quantitative big data analysis, we shed new light on the genetic synergy, the mechanisms and mechanics controlling and driving composite morphogenesis.

This talk is part of the Morphogenesis Seminar Series series.

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