University of Cambridge > Talks.cam > Morphogenesis Seminar Series > First a war then a dance: How sensory organs take shape

First a war then a dance: How sensory organs take shape

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  • UserAnna Erzberger (EMBL Heidelberg, Germany) World_link
  • ClockMonday 18 January 2021, 14:30-16:00
  • HouseOnline.

If you have a question about this talk, please contact ucam-morphogenesis-committee.

https://zoom.us/j/94781964934?pwd=eDQvMUZjV0tTY3hYZ1drYlJmczlNQT09

Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here, we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation of a mechanosensory organ. Combining theory, genetic perturbations and in vivo imaging, we study the development and regeneration of the fluid-motion sensors in the zebrafish’s lateral line. We find that two interacting symmetry-breaking events—one mediated by biochemical signalling and the other by cellular mechanics—give rise to precise rotations of cell pairs, which produce a mirror-symmetric polarity pattern in the receptor organ.

This talk is part of the Morphogenesis Seminar Series series.

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