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University of Cambridge > Talks.cam > pb630's list > RNA communication between pathogens and their hosts.
RNA communication between pathogens and their hosts.Add to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact Paula Bibby. Protein-protein interactions play central roles in the molecular conflict between viruses and their hosts. RNA , another key biological macromolecule, has an inherent capacity to form structures and specific interactions through base-complementarity. However, the prevalence and roles of host-pathogen RNA -RNA interactions remain largely unreachable due to technological limitations. I have recently developed COMRADES , a scalable method for studying dynamic RNA structures and RNA -RNA interactions inside cells, providing high-throughput conformation capture (Hi-C) capabilities to RNA biology. Applying COMRADES to Zika virus inside human and mosquito cells revealed the first-ever structure of a wildtype viral RNA genome inside its host cell, demonstrating an unanticipated level of structural-dynamics. I identified strong evidence for replication-coupled cyclisation of viral RNA genomes, and for multiple site-specific interactions between the viral genome and human noncoding RNAs. I discovered a triple-function element in the viral RNA genome involved in translation, replication, and binding to human microRNA-21. The newly identified structures and interactions uncover a rich and little explored universe of RNA -based communication pathways between cells and their pathogens, which can be harnessed for the design of new antiviral strategies. This talk is part of the pb630's list series. This talk is included in these lists:Note that ex-directory lists are not shown. |
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