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Modes of Collective Cell Migration on 2- and 3-D Substrata

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Cells migrating in sheets or large cohorts tend to behave very differently from cells migrating individually, especially under geometrical or physical constraints and on 2 and 3D substrata. Such distinctive behavior of cells migrating in a collective manner underlies several important biological processes such as wound closure, maintenance of intestinal epithelium, developmental processes and even cancer metastasis. As such, they can also provide important insights towards better tissue repair and regenerative medicine. Here, we characterized the kinematic behavior of epithelial cell cohorts migrating under well defined geometrical constraints and physical confinements such as on a 2D narrow strips and within 3D microtubes.

1. Xi et al., Emergent patterns of collective cell migration under tubular confinement, Nature Communications, 2017. 2. Saw et al., Topological defects in epithelia govern cell death and extrusion, Nature, 2017. 3. Vedula et al., Mechanics of epithelial closure over non-adherent environments, Nature Communications, 2015. 4. Vedula et al., Epithelial bridges maintain tissue integrity during collective cell migration, Nature Materials, 2014. 5. Vedula et al., Emerging modes of collective cell migration induced by geometrical constraints, PNAS , 2012.

Speaker Biography: Professor Lim is the inaugural NUS Society Professor, Founding Principal Investigator of the Mechanobiology Institute as well as Director of the Biomedical Institute for Global Health Research & Technology at the National University of Singapore. His research interests include mechanobiology of human diseases and microfluidic technologies for diagnosis and precision medicine. Prof Lim has authored more than 380 journal papers including in Nature, Nature Materials, Nature Comm, Nature Protocols and PNAS . He is an elected Fellow of both the American Institute for Medical & Biological Engineering and the International Academy for Medical & Biological Engineering as well as elected member of the World Council of Biomechanics. He currently sits on the editorial boards or as Associate Editor of more than 20 international journals. He cofunded 6 startups. Prof Lim and his team have garnered more than 80 research awards and honors including the HFSP Award 2018, International Precision Medicine Conference Prize 2017, Asian Scientist 100 in 2016, ASEAN

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