Genetic analysis of a conserved protein reveals an important role in Plasmodium falciparum merozoite invasion of the host red blood cell

Add to your list(s) Download to your calendar using vCal

• Dr Danny Wilson; Laboratory Head - Malaria Biology, Research Centre for Infectious Diseases, School of Biological Sciences, The University of Adelaide, Australia
• Tuesday 21 May 2019, 12:00-13:00
• Babraham - The Cambridge Building - Kings Hedges Room.

If you have a question about this talk, please contact Bobbie Claxton.

If you would like to attend this seminar, please contact us to arrange site access.

The disease-causing blood stage of the Plasmodium falciparum malaria parasite lifecycle is reliant on initial invasion of the human red blood cell (RBC). Invasion of the host RBC by malaria merozoites is a rapid process that requires co-ordinated interactions between a large number of proteins, many of which have no known function. We have characterised a protein (Peripherally Associated Rhoptry bulb Protein or PfPARP1) as wrapping around the cytosolic face of the club shaped rhoptry bulb membrane, a key organelle that excretes merozoite vaccine candidates during invasion. PfPARP1 lies in close juxtaposition with the rhoptry lumen marker PfRAP1. Attempts to knock-out PfPARP1 were unsuccessful, but glucosamine inducible PfPARP1 knock-down led to a significant growth defect that was caused by direct loss of merozoite invasion. Knock-down of PfPARP1 was associated with changes in rhoptry antigen structure, suggesting that PfPARP1 may have a direct role in rhoptry function that is essential to invasion.

This talk is part of the Babraham Seminar series.

This talk is included in these lists:

• Babraham - The Cambridge Building - Kings Hedges Room
• Babraham Seminar
• Graduate-Seminars
• se393's list

Note that ex-directory lists are not shown.