Targeting Tumor Metabolic Vulnerabilities with a Novel Complex-I Inhibitor: [18F]FAZA PET Imaging of Mechanism-Specific Pharmacodynamics In Vivo

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• David Piwnica-Worms, M.D., Ph.D., Professor and Chair, Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center
• Wednesday 31 October 2018, 14:00-15:00
• CRUK CI Lecture Theatre.

If you have a question about this talk, please contact Adelaide Schiemer.

David Piwnica-Worms, M.D., Ph.D., is Professor and Chair, Department of Cancer Systems Imaging, and Deputy Head, Research Affairs, Division of Diagnostic Imaging at The University of Texas MD Anderson Cancer Center. He earned his bachelor’s degree in Mechanical Engineering from Stanford University, received his medical and doctorate degrees (Cell Physiology) as a Medical Scientist Training Program (MSTP) awardee at Duke University Medical School, completed residency training in diagnostic radiology and a fellowship at the Brigham & Women’s Hospital, followed by his first faculty appointments at Harvard Medical School. For two decades, Dr. Piwnica-Worms was at Washington University School of Medicine in St. Louis, where he was Director of the BRIGHT Institute and the Molecular Imaging Center, driving inter-disciplinary innovation in molecular imaging until 2013, when he was recruited to MDACC . A pioneer and leader in the field of molecular imaging, Dr. Piwnica-Worms has created several innovative strategies to visually capture and measure biological processes in living animals, model systems and humans at the molecular and cellular level using remote imaging detection methods. Dr. Piwnica-Worms has focused on genetically-encoded bioluminescent and PET /SPECT radiotracer reporter systems for imaging signal transduction, protein-protein interactions, and transcriptional regulation of gene expression at scales ranging from single cells to cell populations to live animals and humans in vivo. He was an RSNA Scholar, an established investigator of the American Heart Association, a founding member and former president of the Society for Molecular Imaging and is recipient of the Society for Molecular Imaging Lifetime Achievement Award. Dr. Piwnica-Worms has been honored with a Distinguished Alumnus Award from Duke University Medical School, the Gerald Dewey Dodd, Jr., Endowed Distinguished Chair in Diagnostic Imaging, is a recipent of the Texas STARS Faculty Award, an Elected Fellow of the American Association for the Advancement of Science and an Elected Member of the National Academy of Medicine.

This talk is part of the CRUK CI Lecture Theatre series.

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