University of Cambridge > Talks.cam > Babraham Seminar > Babraham Distinguished Lecture - Elucidating new ways to target downstream of KRAS mutation in colorectal cancer : metabolic and microenvironment targets

Babraham Distinguished Lecture - Elucidating new ways to target downstream of KRAS mutation in colorectal cancer : metabolic and microenvironment targets

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If you have a question about this talk, please contact Matt Humphries.

If you would like to attend this lecture, please contact us to arrange site access *This lecture will conclude with networking drinks*

My laboratory has spent a number of years understanding the key consequences of loss of the APC (Adenomatous Polyposis Coli) gene in vivo. Loss of the gene is common to most colorectal cancers (80%) and is thought to initiate CRC . We have found many of our ways to target APC deficient cells stop working when there is additional mutation of KRAS . KRAS is mutated in 40% of CRC and currently acts a negative indicator for EGFR based therapies. In my talk, I will discuss the work we have down investigating the key mechanistic pathways activated in cells that lose both APC and mutate KRAS . I will focus on our work on metabolism and particularly the SLC7A5 (LAT1 transporter) that link metabolism into protein synthesis.

Finally I will discuss our work developing metastatic models of CRC and key determinants of KRAS mutant CRC . Once again these studies have identified a key role for neutrophils in these models.

This talk is part of the Babraham Seminar series.

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