COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring. |
University of Cambridge > Talks.cam > Babraham Seminar > Babraham Distinguished Lecture - Selective autophagy receptors and LIR-ATG8 interactions in autophagy
Babraham Distinguished Lecture - Selective autophagy receptors and LIR-ATG8 interactions in autophagyAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact Bobbie Claxton. If you would like to attend this Lecture, please contact us to arrange site access *This lecture will conclude with networking drinks* Selective autophagy, the selective degradation of macromolecules or organelles by autophagy, is a crucial quality control process vital for cellular homeostasis and prevention of disease. Cargoes to be degraded are recognized by selective autophagy receptors, like the Sequestosome 1/p62-Like Receptors (SLRs). p62/SQSTM1 and other SLRs couple cargo to the forming autophagosomes, called phagophores, via interactions with the ATG8 family of proteins through a short motif in the autophagy receptors, the LIR motif. ATG8 family proteins are also involved in scaffolding the autophagosome nucleation machinery. We have found that both the ULK1 /2- and class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) complexes as well as ATG4B rely on GABARAP subfamily ATG8 proteins for membrane scaffolding interactions. The targeted clearance of surplus, damaged or dysfunctional mitochondria by autophagy (mitophagy) is one of the most important selective autophagy processes. SLRs are involved in mitophagy in addition to the membrane-bound mitophagy receptors. In a collaborative effort between our group and the group of Anne Simonsen we have found that the mitochondrial matrix proteins NIPSNAP1 (4-Nitrophenylphosphatase domain and non-neuronal SNAP25 -like protein homolog 1) and NIPSNAP2 accumulate on the mitochondrial surface upon mitochondrial depolarization. There they recruit SLRs and ATG8 proteins, thereby functioning as “eat-me” signals for mitophagy. In another study, we have uncovered a novel mitophagy receptor that collaborates with the archetypical SLR , p62/SQSTM1 in the turnover of a subset of mitochondrial membrane proteins by piecemeal basal mitophagy. This talk is part of the Babraham Seminar series. This talk is included in these lists:
Note that ex-directory lists are not shown. |
Other listsAndrew Chamblin Memorial Lecture 2015 The obesity epidemic: Discussing the global health crisisOther talksSustainable Corporate Innovation and Leadership RevolutioN Trains Input-to-State Stability for complex dynamics: From global to almost global… and back Film Screening UNSEEN ENEMY with the director Janet Tobias Quantum Computing - Theory and Practice: The Qubit and Quantum computation |