University of Cambridge > Talks.cam > Babraham Seminar > Hypothalamic control of body weight: the role of protein degradation systems in a high-fat diet-induced obesity model

Hypothalamic control of body weight: the role of protein degradation systems in a high-fat diet-induced obesity model

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Protein degradation systems are critical to the maintenance of cellular proteostasis. In the central nervous system (CNS) impairment of the ubiquitin-proteasome system and autophagy are linked to neuronal dysfunction in many neurodegenerative diseases. The hypothalamus is one of the main areas of the CNS that is responsible for the control of food intake and neuronal dysfunction in this area is one of the hallmarks of obesity pathophysiology. In this talk I will lead you through the physiology of the hypothalamic control of food intake and will present data showing that dysregulation of protein degradation systems in the hypothalamus is connected to hypothalamic dysfunction in high-fat diet-induced obese mice.

This talk is part of the Babraham Seminar series.

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