Babraham Lecture - Cellular responses to DNA damage: from mechanistic insights to applications in cancer therapy

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• Prof. Steven Jackson; Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
• Tuesday 11 September 2018, 14:00-15:00
• Babraham - The Cambridge Building; Petersfield Lecture Theatre.

If you have a question about this talk, please contact Bobbie Claxton.

If you would like to attend this Lecture, please contact us to arrange site access *This lecture will conclude with networking drinks*

As DNA is frequently subject to a wide array of molecularly distinct forms of damage, life has evolved multiple DNA repair and associated processes, collectively termed the DNA -damage response (DDR). The importance of DDR mechanisms is underlined by their deregulation or loss causing cancer and various human genetic disorders whose pathologies include stem-cell exhaustion, developmental defects, infertility, immune-deficiency, neuro-degeneration, cancer predisposition and/or premature ageing. Work in my laboratory aims to decipher DDR mechanisms, particularly those triggered by DNA double-strand breaks. In this talk, I will describe some of our recent work using CRISPR -Cas9 genetic screens and ensuing mechanistic studies to identify new DDR factors/regulators and then define their functions. I will also explain how such work is identifying new avenues for anti-cancer therapy and is helping us understand how cancer cells can evolve resistance to therapeutic agents.

This talk is part of the Babraham Seminar series.

This talk is included in these lists:

• Babraham - The Cambridge Building; Petersfield Lecture Theatre
• Babraham Seminar
• Graduate-Seminars
• se393's list

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