BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//talks.cam.ac.uk//v3//EN
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
TZNAME:BST
DTSTART:19700329T010000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
TZNAME:GMT
DTSTART:19701025T020000
RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
CATEGORIES:CamBioScience's Two-day Intensive courses in Emerg
 ing Life Science Technologies
SUMMARY:EMERGING EPIGENETICS: DETECTING &amp\; MODIFYING E
 PIGENETICS MARKS - Speaker to be confirmed
DTSTART;TZID=Europe/London:20180312T080000
DTEND;TZID=Europe/London:20180312T210000
UID:TALK97402AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/97402
DESCRIPTION:The sequence of DNA within every cell of a multice
 llular organism is essentially equivalent and inva
 riable. However\, multicellular organisms are made
  of hundreds of cell types\, each with unique cell
 ular programs\, morphologies and functions. This i
 ncredible variety results from the regulation of t
 he epigenome\, which consists of the chromatin and
  its chemical modifications. The epigenome is dyna
 mic and acts as an interface between environmental
  signals and the genetic code.\n\nAlterations in e
 pigenetic programming affect gene function in the 
 absence of an underlying change in the DNA sequenc
 e via a number of mechanisms which include:\n\nHis
 tone post-translational modifications: methylation
 \, phosphorylation\, acetylation\, sumoylation\, a
 nd ubiquitination.\nDNA methylation and hydroxymet
 hylation.\nSmall noncoding RNAs\, termed microRNAs
  or ncRNAs which can silence chromatin\, degrade m
 RNA\, or block translation\nTechnological advances
 \, such as chromatin immunoprecipitation followed 
 by next-generation sequencing (ChIP–Seq)\, and var
 iations on this\, have enabled the analysis of the
  epigenome at base-pair resolution and allowed ‘ep
 igenomic profiling’ in both normal and abnormal ce
 lls and tissues. Epigenomic profiling has already 
 proved invaluable by helping to better define crit
 ical DNA control elements\, such as gene enhancers
  and promoters.\n\nNumerous human diseases are cha
 racterised by a departure from the normal pattern 
 of gene expression and errors in epigenetic proces
 ses underpin many of these. However\, the reversib
 le nature of most of the known epigenetic modifica
 tions of chromatin offer promising therapeutic opp
 ortunities for the controlled regulation of diseas
 e-related genes via the manipulation of epigenetic
  mechanisms. With the development of a new suite t
 ools including CRISPR mediated ‘epigenome-editing’
 \, epigenetics will continue to be one of the most
  innovative research areas in the life sciences an
 d medicine.\n\nOn this two-day intensive course yo
 u will:\n\n* Understand the constituent components
  and mechanisms of the epigenome\n* Get to grips w
 ith the very latest tools and technology for readi
 ng and decoding the epigenome.\n* Learn how to ove
 rcoming common pitfalls for wet-lab based epigenet
 ics methods.\n* Gain an appreciation of bioinforma
 tics approaches for analysing epigenetic datasets.
 \n* Be introduced to CRISPR mediated epigenome edi
 ting and its potential applications.\n* Extend you
 r network of expert contacts from all over the wor
 ld.\n*Receive a Certificate of Completion.\n\nVisi
 t our VIDEO ROOM for impressions of our past cours
 es.
LOCATION:Homerton College - CB2 8PH
CONTACT:Dr. Chibeza C. Agley
END:VEVENT
END:VCALENDAR