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SUMMARY:Innovations in Drug Delivery by Supramolecular Design - Eric Andre
 w Appel\, PhD\, Assistant Professor Stanford University
DTSTART:20171110T144500Z
DTEND:20171110T151500Z
UID:TALK95392@talks.cam.ac.uk
CONTACT:46601
DESCRIPTION:"Supramolecular biomaterials exploit rationally-designed non-c
 ovalent interactions to enable innovative approaches to drug formulation a
 nd delivery. For example\, supramolecular interactions can be used to dyna
 mically cross-linking polymer networks\, yielding shear-thinning and self-
 healing hydrogels that allow for minimally invasive implantation in vivo t
 hough direct injection or catheter delivery to tissues. \nAlternatively\, 
 rationally designed high-affinity interactions can be used to non-covalent
 ly modify therapeutic proteins\, endowing them with prosthetic function su
 ch as enhanced stability in formulation or extended activity in vivo. Here
 in\, we discuss the preparation and application of shear-thinning\, inject
 able hydrogels driven by dynamic non-covalent interactions between modifie
 d biopolymers (BPs) and biodegradable nanoparticles (NPs) comprised of pol
 y(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA). Owing to the non-c
 ovalent interactions between PEG-b-PLA NPs and BPs\, the hydrogels flow un
 der applied stress and their mechanical properties recover completely with
 in seconds when the stress is relaxed\, demonstrating the shear-thinning a
 nd injectable nature of the material. Moreover\, the hierarchical construc
 tion of these biphasic hydrogels allows for multiple therapeutic compounds
  to be entrapped simultaneously and delivered either co-delivered or deliv
 ered independently of one another in a user-defined manner with release pr
 ofiles that are tunable over several months. These materials open new oppo
 rtunities to address fundamental biological questions in immunotherapy as 
 well as to enable passive immunity strategies and long-term treatment of a
  variety of chronic disease targets. Further\, we will discuss the use of 
 supramolecular interactions to append functionality to therapeutic protein
 s for applications in formulation and therapy. This non-covalent approach 
 to modification of authentic proteins is highly modular and allows for for
 mulation of historically incompatible proteins. Overall\, this presentatio
 n will demonstrate the utility of a supramolecular approach to the design 
 of biomaterials affording unique opportunities in the formulation and cont
 rolled release of therapeutics.\n
LOCATION:Oatley Seminar Room\, Department of Engineering
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