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SUMMARY:Phase-coupling Resting-State Networks (RSNs) from human intra-cran
 ial recordings comprise functionally related\, spatially contiguous region
 s - Nitin Williams\, University of Helsinki
DTSTART:20171023T113000Z
DTEND:20171023T123000Z
UID:TALK93796@talks.cam.ac.uk
CONTACT:Johan Carlin
DESCRIPTION:Resting-state brain activity exhibits two distinct modes of co
 upling between brain regions\, i.e. coupling between amplitude envelopes a
 nd coupling between phases of neuronal oscillations. RSNs (Resting-State N
 etworks) of coupling between amplitude envelopes have been identified with
  fMRI and MEG\, and supposedly reflect sets of regions whose excitability 
 is co-modulated. However\, not much is known about RSNs of phase-coupling\
 , which might reflect sets of regions between which communication is regul
 ated. In this study\, we identified phase-coupling RSNs from intra-cranial
  EEG recordings of 64 subjects\, at 18 frequency levels from 3-320 Hz. We 
 measured activity from neuronal populations using white-matter referencing
  and used community detection methods from graph theory to identify RSNs f
 rom whole-brain networks of phase-coupling. First\, we found evidence that
  phase-coupling RSNs have a multi-scale organisation such that they can be
  recovered at multiple levels of spatial detail. Next\, we found that phas
 e-coupling RSNs at different frequency levels could be grouped such that e
 ach group corresponded to well-known frequency bands (delta\, theta/alpha\
 , beta\, gamma etc.). Finally\, we found that phase-coupling RSNs up to 80
  Hz comprise spatially contiguous regions that are known to be functionall
 y related. These findings support the functional relevance of resting-stat
 e dynamics and provide new information on those sets of regions that are f
 unctionally interacting at rest\, over and above those revealed by fMRI RS
 Ns.
LOCATION:Lecture Theatre\, MRC Cognition and Brain Sciences Unit\, 15 Chau
 cer Road\, Cambridge
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