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SUMMARY:Gaining control of DNA-based nanodevices  - Prof. Francesco Ricci\
 , Chemistry Department\, University of Rome\, Tor Vergata
DTSTART:20171027T150000Z
DTEND:20171027T160000Z
UID:TALK87081@talks.cam.ac.uk
CONTACT:Lorenzo Di Michele
DESCRIPTION:Nature has invented a number of tricks and strategies by which
  the behaviour of proteins and other biomolecular machines can be finely c
 ontrolled. These highly optimized and evolved mechanisms allow to control 
 biological pathways with different chemical and environmental stimuli and 
 are at the basis of the high specificity and selectivity of biomolecular m
 achines. \n\nMotivated by the above arguments we have characterized and re
 created in-vitro several mechanisms to control the response of DNA-based n
 anodevices for diagnostic and drug-delivery applications (1-2). \n\nUsing 
 these mechanisms we can finely control the activity of DNA-based nanodevic
 es with different chemical and environmental stimuli including pH (3-8)\, 
 antibodies (2-3)\, enzymes (9)\, small molecules (10) and electronic input
 s (11). \n\nI will present an overview of the most representative and rece
 nt examples developed in our lab in the above research directions and I wi
 ll give a brief presentation of the new routes and possibilities that thes
 e results offer. \n\n\nReferences\n[1]	Porchetta. A.\, et al.\, J. Am. Che
 m. Soc.\, 2013\, 135\, 13238.\n[2]	Ranallo\, S. et al.\, Angew. Chem.\, 20
 15\, 54\, 13214.\n[3]	Ranallo\, S. et al.\, Nat. Commun.\, 2017\, 8\, 1515
 0.\n[4]	Idili\, A. et al.\, Nano Lett.\, 2015\, 15\, 5539.\n[5]	Porchetta\
 , A\,   et al. Nano Lett.\, 2015\, 15\, 4467.\n[6] 	Amodio\, A. et al.\, J
 . Am. Chem. Soc.\, 2014\, 136\, 16469.\n[7]	Idili\, A. et al.\, J. Am. Che
 m. Soc.\, 2014\, 136\, 5836.\n[8] 	Mariottini\, D. et al.\, Nano Lett.\, 2
 017\, 17\, 3225.\n[9] 	Amodio\, A. et al.\, J. Am. Chem. Soc.\, 2016\, in 
 press.\n[10]	Del Grosso\, E. et al.\, Nano Lett.\, 2015\, 15\, 8407.\n[11]
 	Ranallo\, S. et al.\, Chem. Sc.\, 2016\, 7\, 66-71.\n
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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