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SUMMARY:Max Perutz Lecture-On clocks and tuners: cyanobacterial strategies
  to thrive in a dynamic environment Erin K. O’Shea\, Harvard University\
 , Howard Hughes Medical Institute - Erin O'Shea
DTSTART:20171115T110000Z
DTEND:20171115T120000Z
UID:TALK76071@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Organisms across all kingdoms of life have evolved circadian c
 locks to temporally align biological activities with diurnal changes in th
 e environment.  In the cyanobacterium Synechococcus elongatus the core osc
 illator is comprised of the proteins KaiA\, KaiB\, and KaiC that generate 
 oscillations in the phosphorylation state of KaiC.  Time encoded in the ph
 osphorylation state of KaiC is transmitted to the master transcriptional r
 egulator RpaA to generate changes in circadian gene expression. Although t
 he circadian output does not affect growth in constant light conditions\, 
 it has substantial effects on fitness in cycling conditions when dark and 
 light periods alternate. In my talk I will describe our findings that reve
 al why the circadian system is important under cycling conditions and how 
 cellular physiology is altered in these conditions.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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