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SUMMARY:Ion Channels as Targets for CNS Disease - Prof. Derek Bowie\,Depar
 tment of Pharmacology and Therapeutics McGill University
DTSTART:20170620T150000Z
DTEND:20170620T160000Z
UID:TALK72954@talks.cam.ac.uk
CONTACT:Dr Mike Edwardson
DESCRIPTION:The Bowie lab uses a combination of techniques to study ionotr
 opic glutamate receptors (iGluRs)\, GABAA receptors and more recently\, N
 a+ channels. All ion channel families are widespread in the vertebrate br
 ain and fulfil many important roles in healthy individuals\, as well as be
 ing implicated in disease states associated with postnatal development (e.
 g. autism\, schizophrenia)\, cerebral insult (e.g. stroke\, epilepsy) and 
 aging disorders (e.g. Alzheimer's disease\, Parkinsonism). Each ion-channe
 l family is studied at two inter-related levels. In structural terms\, ion
 -channel activation mechanisms are examined to provide insight into develo
 ping novel therapeutic compounds. At the level of brain circuits\, we are 
 studying the role of ion-channels in CNS disease. The talk will focus on r
 ecent findings linking deficits in glutamatergic signaling to the neurodev
 elopmental disorder\, Fragile-X syndrome.
LOCATION:Department of Pharmacology Lecture Theatre\, Tennis Court Road
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