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CATEGORIES:Babraham Seminar
SUMMARY:EU LIFE Lecture - &quot\;Histone Chaperones Mainta
 in Cell Fates and Antagonize Reprogramming in C. e
 legans and Human Cells&quot\;        - Dr Baris Tu
 rsun\; Berlin Institute for Medical Systems Biolog
 y (BIMSB)\, Max Delbrück Center (MDC) for Molecula
 r Medicine in the Helmholtz Association
DTSTART;TZID=Europe/London:20171012T130000
DTEND;TZID=Europe/London:20171012T140000
UID:TALK72865AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/72865
DESCRIPTION:Understanding the mechanisms that safeguard cellul
 ar identities is key to improving cell fate reprog
 ramming\, which is of great biological and medical
  importance. We are using C. elegans as a model or
 ganism to identify factors that act as barriers fo
 r cellular reprogramming. C. elegans allows in viv
 o large-scale genetic screens and around 60% of it
 s genes have human homologs. We previously identif
 ied that the histone chaperone LIN-53\, homolog of
  human CAF-1p48\, protects germ cells from being d
 irectly reprogrammed into neurons (Tursun et al.\,
  2011 Science). In an analogous study\, CAF-1 was 
 shown to act as a barrier for cellular reprogrammi
 ng of mouse embryonic fibroblasts (Cheloufi et al.
 \, 2015 Nature). Such striking conservation from w
 orm to mouse implies that reprogramming barriers m
 ight be shared among C. elegans and humans. We per
 formed a whole-genome RNAi screen against all 20.0
 00 genes of C. elegans and identified around 160 n
 ovel factors that counteract reprogramming of diff
 erent cells into specific glutamatergic neurons. T
 esting a number of the newly identified factors in
  human fibroblasts revealed the essential chromati
 n regulator FACT (FAcilitates Chromatin Transcript
 ion) as an evolutionarily conserved barrier for ce
 ll fate reprogramming (Kolundzic et al.\, in revis
 ion). \nAdditionally\, we are studying whether reg
 ulation of reprogramming is linked with Aging regu
 lation. Several observations in our lab suggest th
 at reprogramming factors are implicated also in li
 fespan maintenance suggesting a link between safeg
 uarding cell fates\, cellular homeostasis and the 
 control of Aging.\n
LOCATION:Babraham - The Brian Heap Seminar Room
CONTACT:Bobbie Claxton
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