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SUMMARY:NMR spectroscopy to study dynamics with applications to immunology
  and neurodegeneration - Professor Christian Griesinger\,  Max Planck Inst
 itute for Biophysical Chemistry\, Göttingen
DTSTART:20170517T093000Z
DTEND:20170517T103000Z
UID:TALK72529@talks.cam.ac.uk
CONTACT:23027
DESCRIPTION:Kinetics of protein dynamics will be discussed on examples of 
 folded and unfolded proteins (1). The role of partially disordered protein
 s in two fields of research is investigated. One is the adaptor protein SL
 P65 which interacts with CIN85 (2). The two proteins are essential for B c
 ell activation. The protein is found to be mainly unstructured and its var
 ious segments entertain different functions or interact with membranes\, S
 H3 domains and forming coiled coils. Based on the structures\, a molecular
  lego will be described that reduces the SLP65/CIN85 interaction to its ab
 solutely necessary essentials. The two proteins can perform phase separati
 on which is related to function.\nWe are additionally interested in a clas
 s of IDPs that are important in neuro- and cellular degeneration\, which f
 orm oligomers and fibrils. Interference with these aggregates specifically
  on the oligomer level proves to be a valid concept for treatment of devas
 tating diseases such as Parkinson’s\, Alzheimer’s\, Creutzfeldt Jacob 
 disease and Type II diabetes mellitus (3). \n\n\n(1) C. Smith et al. Proc.
  Natl. Acad. Sci. USA. 113\, 3296-74 (2016)\; C. Smith et al. Angew. Chem.
  Int. Ed. 54\, 207-10 (2015)\n\n(2) M. Engelke et al. Science signaling: 7
  (339) ra79 (2014)\; J. Kühn et al. Science signaling: 9 (434) ra66 (2016
 )\n\n(3) C.W. Bertoncini et al. PNAS 102\, 1430-1435 (2005)\; P. Karpinar 
 et al. EMBO J 28\, 3256-3268 (2009)\; J. Wagner et al. Acta Neuropath. 125
 \, 795-813 (2013)\; A.A. Deeg\, Biochim. Biophys. Act. 1850 (9)\, 1884-189
 0 (2015)\; S. Shi\, J. Neuropath. Exp. Neurol. 74(9) 924-933 (2015)\; J. W
 agner et al. Act. Neuropath.130\, 619-631 (2015)\n
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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