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CATEGORIES:Cambridge Cardiovascular Seminar Series
SUMMARY:Genetic Prediction of Cardiovascular Disease - Pro
 f. Frank Dudbridge - University of Leicester
DTSTART;TZID=Europe/London:20170629T130000
DTEND;TZID=Europe/London:20170629T140000
UID:TALK70540AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/70540
DESCRIPTION:Identification of individuals at risk of cardiovas
 cular disease is important for primary prevention 
 strategies such as the prescription of statins to 
 high risk groups.  Epidemiological risk scores suc
 h as QRISK2 have proved clinically useful for such
  purposes\, but the substantial heritability of ca
 rdiovascular disease suggests that genotypic data 
 should provide substantial improvements in predict
 ive accuracy.  Genomewide association studies in l
 arge cohorts have discovered dozens of genetic var
 iants associated with CVD\, but their utility for 
 individual risk prediction has so far proved modes
 t.  I will review recent studies of genetic predic
 tion in CVD and present theoretical results sugges
 ting that substantial improvements over epidemiolo
 gical risk scores may soon be possible.  I will di
 scuss applications of genetic prediction to multip
 le traits at once\, and propose some novel statist
 ical measures of accuracy for this situation.
LOCATION:University of Cambridge Biomedical Campus (Addenbr
 ooke’s Hospital Site) Clinical School Building Lec
 ture Theatre 2
CONTACT:
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