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SUMMARY:Preeclampsia and the risk of cardiovascular disease in later life 
 - Dr. Andreas Brueckmann\, Department Of prenatal diagnosis And preventive
  medicine\, Erfurt\, Germany
DTSTART:20170221T153000Z
DTEND:20170221T160000Z
UID:TALK69805@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Preeclampsia is considered as a disease of the maternal endoth
 elium and the proper function of the microvascular endothelium includes ma
 intenance of a barrier and regulation of vascular tone. However\, the exte
 nt to which microvascular dysfunction results from endothelial dysfunction
 \, sympathetic influence\, neuronal or myogenic disturbance\, increased pe
 rmeability or   microangiopathy\, at different levels of risk for preeclam
 psia and in different vascular beds\, remains uncertain. Summarizing\, it 
 is hypothesized that in preeclampsia a preexisting endothelial dysfunction
  and a consequently increased permeability results in a disturbed microvas
 cular reactivity and autoregulation that also affects the placenta. Beyond
  the persistent peripheral vasoconstriction\, due to sympathetic overactiv
 ity\, the microcirculation exhibits blood flow regulative competence to co
 unteract the impaired macrovascular endothelial function. The disruption o
 f this microvascular autoregulatory competence\, with further disease prog
 ression and the resulting atherosclerotic changes\, which are partially ge
 netically determined\, indicate an increased risk for future cardiovascula
 r disease. The analysis of the microcirculation\, at different risk for pr
 eeclampsia and in different vascular beds\, might be important to detect w
 omen susceptible to preeclampsia\, by unmasking preexisting differences an
 d to enable therapeutic strategies. Pathological microvascular findings af
 ter and during preeclampsia and screening strategies for preeclampsia\, de
 tected with different assessment methods\, are summarized in this chapter.
LOCATION:Online
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