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SUMMARY:Enzyme-based antibacterials against skin infections - Dr Yves Brie
 rs\, Ghent University – Campus Schoonmeersen\, Gent\, Belgium
DTSTART:20170131T080000Z
DTEND:20170131T083000Z
UID:TALK69759@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Artilysin®s represent a novel\, promising class of antibacter
 ials\, combining the lytic power of bacteriophage-encoded endolysins and o
 uter membrane penetrating peptides. Selected peptides that locally destabi
 lize the outer membrane of Gram-negative bacteria have been covalently fus
 ed to endolysins that degrade the peptidoglcyan layer. These peptides prom
 ote the transfer of the fused endolysin to the peptidoglycan layer across 
 the outer membrane. Time-lapse microscopy has shown that cells are killed 
 within seconds. The efficacy of Artilysin®s has been demonstrated in an i
 n vitro keratinocyte infection model and in case studies of skin infection
 s.\n
LOCATION:Online
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