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SUMMARY:Three-dimensional cell culture in micro-patterned hydrogels  - Pro
 fessor Esmaiel Jabbari\, University of South Carolina\, Columbia\, SC\, Un
 ited States
DTSTART:20170207T143000Z
DTEND:20170207T150000Z
UID:TALK69743@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Increasing evidence suggests that the tumor heterogeneity is r
 ooted in the existence of a very small sub-population of stem-like cells (
 CSCs) within the population of tumor cells. Since cancer takes many years 
 to grow\, it is important to develop in vitro models to study tumor initia
 tion and progression. In an effort to regulate the cancer cell microenviro
 nment\, my laboratory has merged material synthesis\, microscale technolog
 ies\, and cancer biology to develop an engineered 3D matrix to delineate t
 he role of individual factors in the tumor microenvironment on CSC mainten
 ance\, self-renewal\, and differentiation. I will demonstrate in my talk t
 hat engineered matrices can enrich the CSC subpopulation of cancer cells w
 hich is potentially useful in cancer drug screening and personalized cance
 r treatment.
LOCATION:Online
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