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SUMMARY:Modelling cardiovascular and metabolic disease using transgenic ze
 brafish - Dr Marcel den Hoed\, Department of Medical Sciences\, Molecular 
 Epidemiology and SciLifeLab\, Uppsala University.
DTSTART:20181214T123000Z
DTEND:20181214T133000Z
UID:TALK68999@talks.cam.ac.uk
CONTACT:43208
DESCRIPTION:Genome-wide association studies identified hundreds of loci th
 at are associated with cardiometabolic diseases and risk factors. For most
  loci the causal genes remain unknown. My group developed experimental pip
 elines that facilitate image-based genetic screens in zebrafish larvae by 
 using: 1) the zebrafish’ well-annotated genome\; 2) CRISPR-Cas9 based mu
 tagenesis\; 3) fluorescent transgenes and dyes\; 4) automated positioning 
 and imaging technologies\; 5) custom-written image quantification pipeline
 s. Results from dietary\, drug and genetic screens confirm that zebrafish 
 larvae represent an opportunity to identify causal genes for cardiometabol
 ic diseases and risk factors\, and increase our understanding of disease a
 etiology.
LOCATION:Meeting rooms\, Level 4 Institute of Metabolic Sciences\, Addenbr
 ooke’s Treatment Centre (ATC)
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