BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:DNA Microarray Technology at Agilent Technologies: Engineering\, M
 anufacturing and Applications - Bill Peck\,  Agilent Technologies\, Santa 
 Clara California
DTSTART:20070425T131500Z
DTEND:20070425T141500Z
UID:TALK6891@talks.cam.ac.uk
CONTACT:Timothy G. Griffin
DESCRIPTION:This seminar will discuss aspects of DNA microarray technology
  with emphasis placed on engineering aspects of the in-situ DNA microarray
  manufacturing process implemented by Agilent Technologies of Santa Clara\
 , California.  A DNA microarray (also commonly known as gene chip or genom
 e chip\, DNA chip\, or gene array) is a collection of discrete micron-scal
 e sites (features) within which unique sequences of DNA are attached to a 
 planar solid surface. This surface is often composed of glass\, plastic or
  silicon.  This collection of features form an addressable two-dimensional
  array of approximately 240\,000 DNA probes on a standard microscope slide
  format that can be used in a variety of ways to answer biological questio
 ns.\n\nAgilent's in-situ manufacturing process relies on picolitre-scale d
 eposition of reactive chemistries at discrete locations to synthesize mole
 cules in place on the slide surface\, building the polymer one base at a t
 ime. This process differs from conventional deposition based\n(spotted) mi
 croarrays that deposit pre-synthesized molecules at discrete locations. We
  will review technical aspects of the inkjet based in-situ microarray prin
 ting process and discuss some of the problems encountered when driving to 
 higher density.\n\nIllustrative examples of microarray application technol
 ogies used to answer biological questions will be presented with emphasis 
 on the aCGH (array Comparative Genomic Hybridization) platform.  This tech
 nology has recently revolutionized the field of chromosomal aberration det
 ection.\nAberrations such as chromosome rearrangements are commonly associ
 ated with multiple disease states such as cancer and many developmental sy
 ndromes.\n\nWe will end with a brief discussion of interesting future and 
 proposed uses of microarray technology ranging from microbiological applic
 ations in the ocean to the search for life on other planets.\n\n\nBiograph
 y:\n\nDr Peck received his BSc in Mechanical Engineering from the Universi
 ty of Alberta in 1991. While an undergraduate\, Dr. Peck began working wit
 h Prof. Sigurdson on a summer research project in 1989.  This work was aim
 ed at understanding the complex mechanisms controlling and the structures 
 created by impacting droplets. Dr Peck went on to complete an MSc and PhD 
 in the same area under Prof. Sigurdson's supervision.  Dr Peck continued h
 is work on interfacial flows and vortex dynamics while a Post Doc at the C
 enter for Turbulence Research jointly run by Stanford and NASA-Ames Resear
 ch Center. In 2000 Dr Peck joined Agilent Technologies\, Santa Clara\, Cal
 ifornia (formerly Hewlett Packard) where he is now the genomics R&D princi
 pal engineer developing their inkjet-based DNA microarray manufacturing pl
 atform.
LOCATION:Lecture Theatre 1\, Computer Laboratory
END:VEVENT
END:VCALENDAR