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SUMMARY:"The Analysis of Recurrent Events: A Summary of Methodology and In
 formative Censoring Considerations" - Dr Jennifer Rogers\, University of O
 xford
DTSTART:20161018T133000Z
DTEND:20161018T143000Z
UID:TALK67162@talks.cam.ac.uk
CONTACT:Alison Quenault
DESCRIPTION:Many chronic diseases are characterised by nonfatal recurrent 
 events.  Examples of such include asthma attacks in asthma\, epileptic sei
 zures in epilepsy and hospitalisations for worsening condition in heart fa
 ilure.  Analysing all of these repeat events within individuals is more re
 presentative of disease progression and more accurately estimates the effe
 ct of treatment on the true burden of disease.  This talk will start by ou
 tlining the different methods that are available for analysing recurrent e
 vent data.  We shall illustrate and compare various methods of analysing d
 ata on repeat hospitalisations using simulated data and data from major tr
 ials in heart failure.\n\nAn increase in heart failure hospitalisations is
  associated with a worsening condition and a subsequent elevated risk of c
 ardiovascular death\, meaning that subjects may die during follow-up.  A c
 omparison of heart failure hospitalisation rates\, between treatment group
 s\, can be confounded by this competing risk of death and any analyses of 
 recurrent events must take into consideration informative censoring that m
 ay be present. I shall outline the different methods available for analysi
 ng recurrent events in the presence of dependent censoring and the relativ
 e merits of each method shall be discussed.  In addition\, data from multi
 ple large scale clinical trials in cardiovascular disease shall be used to
  illustrate the application of these methods.  Future directions for recur
 rent events analysis shall also be considered.\n
LOCATION:Large  Seminar Room\, 1st Floor\, Institute of Public Health\, Un
 iversity Forvie Site\, Robinson Way\, Cambridge
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