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SUMMARY:RNA methylation in development and disease - Michaela Frye\, Stem 
 Cell Institute and Department of Genetics\, Cambridge
DTSTART:20161122T110000Z
DTEND:20161122T120000Z
UID:TALK66279@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Many of the over 100 types of chemical RNA modifications ident
 ified in organism of all kingdoms of life are are functionally indispensab
 le for protein synthesis because they regulate translational speed and acc
 uracy. Accordingly\, loss-of-function mutations in enzymes responsible for
  the formation of RNA modifications can cause severe human diseases includ
 ing neuro-developmental disorders\, mitochondrial diseases\, diabetes\, an
 d cancer. Here\, I will focus on the formation of 5-methylcytidine in RNA 
 and show how loss of RNA methylation mechanistically affects protein trans
 lation and thereby regulates the cellular response to environmental stress
  stimuli. This is important because these newly discovered biological role
 s of RNA methylation directly influence cell fate decision in normal tissu
 e development and tumour formation.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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