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SUMMARY:Modeling and stochastic analysis of autoregulation of the Krox20 t
 ranscription factor driving cellular diversification and hindbrain pattern
 ing - Jürgen Reingruber (CNRS - Ecole Normale Superieure Paris)
DTSTART:20160517T140000Z
DTEND:20160517T150000Z
UID:TALK66111@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:I will present the molecular implementation and function of th
 e autoregulatory loop that amplifies and maintains the expression of Krox2
 0\, a transcription factor governing vertebrate hindbrain&nbsp\;segmentati
 on. By combining data analysis\, biophysical modeling\,&nbsp\;stochastic a
 nalysis and simulations\, I dissect the autoregulation&nbsp\;process as a 
 function of an initiation signal that leads to promoter&nbsp\;activation a
 nd subsequent mRNA and protein production. Autoregulation&nbsp\;generates 
 a bistable switch that turns a transient initiation signal into a persiste
 nt cell fate. The duration and strength of the input&nbsp\;signal controls
 &nbsp\; patterning by modulating the distribution between the  cell fates.
LOCATION:Seminar Room 2\, Newton Institute
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