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SUMMARY:Inferring neural circuit mechanisms that underlie memory storage a
 nd decision making in the human brain   - Helen Barron\, University of Oxf
 ord
DTSTART:20160321T144500Z
DTEND:20160321T154500Z
UID:TALK63993@talks.cam.ac.uk
CONTACT:Paula Kaanders
DESCRIPTION:Neural circuit level descriptions of cognitive processes are d
 ifficult to measure in humans\, but can provide important insight into bra
 in function. Here I will present two sets of studies that illustrate how n
 on-invasive measurements of the human brain can be used to index  neural c
 ircuit mechanisms responsible for  memory and decision-making. In the firs
 t set of studies\, I will ask how memories are stored in cortex given that
  learning disrupts the precise balance between excitation and inhibition. 
 To address this question  I combine 7T fMRI and MRS with transcranial dire
 ct current stimulation\,and show that recently established memories lie do
 rmant in cortex but can be unmasked when the concentration of cortical GAB
 A is down-regulated. This data suggests that during memory formation\, mod
 ifications at excitatory synapses are complimented by proportional changes
  at inhibitory synapses. In the second set of studies\, I will ask how mem
 ories can be used to represent novel experiences\, to facilitate evaluatio
 n and choice of novel items. Using representational fMRI\, I will show tha
 t novel experiences are represented by combining multiple memories in hipp
 ocampus and prefrontal cortex. This suggests that in the absence of direct
  experience\, existing memories can be compiled to allow for imagination o
 f  future choices.
LOCATION:Ground Floor Lecture Theatre\, Department of  Psychology
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