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SUMMARY:Perutz Lecture 2016 - Ron Vale\, University of California
DTSTART:20160602T100000Z
DTEND:20160602T110000Z
UID:TALK58752@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The T cell immune response is initiated when the major histoco
 mpatibility complex (MHC) protein on the surface of an antigen-presenting 
 cell (APC) interacts with the T-cell receptor (TCR) on a T lymphocyte.  We
  are attempting to understand the initial events in signal propagation usi
 ng a reductionist approach.   In cells\, we have replaced the normal T cel
 l receptor with a “chimeric” receptor that can be engineered to study 
 how variations in ligand binding affinity are transduced into intracellula
 r signals.  We also have been reconstituting biochemical reactions in the 
 signalling pathway.  With ~12 purified proteins or protein complexes\, we 
 have been able to reconstitute the signalling pathway from TCR phosphoryla
 tion to the nucleation of actin polymerization on planar lipid bilayers. T
 his work illustrates how biochemical reconstitution combined with light mi
 croscopy can be used to dissect the biochemical network that underlies the
  T cell signalling cascade.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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