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SUMMARY:Nitric Oxide controls a switch between degenerative and regenerati
 ve phases of developmental neuronal remodelling - Oren Schuldiner\, Ph.D\,
  Department of Molecular Cell Biology\, Weizmann Institute of Science\, Is
 rael
DTSTART:20141114T100000Z
DTEND:20141114T110000Z
UID:TALK55240@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Neuronal remodeling is essential  to refine neural circuits du
 ring normal development of vertebrates and invertebrates. Remodelling ofte
 n involves axon fragmentation and elimination followed by axon regrowth. H
 ow neurons switch between these developmental growth states is mostly unkn
 own. Using the stereotypic remodelling of the Drosophila mushroom body (MB
 ) as a model\, we have uncovered a switching mechanism between degenerativ
 e axon pruning and axonal regrowth. In my lecture\, I will unravel this me
 chanism which is orchestrated by nitric oxide (NO) levels and executed\, a
 t least in part\, by two heme-binding nuclear receptors and the TOR pathwa
 y.
LOCATION:Klug Seminar Room\, Medical Research Council (MRC) (MRC Laborator
 y of Molecular Biol
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