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SUMMARY:Making 'Dopamine Movies' of Cigarette Smoking in the PET Scanner. 
  Finding differences between Men and Women Smokers - Evan D Morris\,  Asso
 ciate Professor Yale University
DTSTART:20140528T110000Z
DTEND:20140528T120000Z
UID:TALK52580@talks.cam.ac.uk
CONTACT:Heather Carlyon
DESCRIPTION:The precise pattern of dopamine fluctuation over time in the p
 resence of a rewarding stimulus may be an important aspect of the addictiv
 e liability of the stimulus.  Cigarette smoking is one such stimulus but s
 ynaptic dopamine in the striatum is elevated for only a short time followi
 ng cigarette smoking. Because the smoking-induced fluctuations are short-l
 ived (on the order of minutes) they cannot be detected or measured reliabl
 y with standard PET kinetic models that presume time-invariant kinetic par
 ameters and steady levels of endogenous neurotransmitters.  Our group has 
 been working on models for extracting temporal information about dopamine 
 levels from dynamic PET data. Our model (‘ntPET’) include time-varying
  components to account for dopamine fluctuations.  When applied at the vox
 el level (‘lpntPET’)\, the model outputs can be visualized as a ‘dop
 amine movie’ which envision as a spatio-temporal signature of addiction.
 \nThis presentation will explore the rationale for\, and creation of dopam
 ine movies as a new functional imaging endpoint.  Data will be presented f
 rom a preliminary study of men and women smoking cigarettes in the PET sca
 nner. We believe our findings may help to shed light on known behavioral d
 ifferences between men and women smokers.\n
LOCATION:Herchel Smith Building for Brain and Mind Sciences\, Forvie Site\
 , Addenbrooke’s
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