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SUMMARY:Energy barriers and cell migration in densely packed tissues - Bi\
 , D (Syracuse University)
DTSTART:20140225T161500Z
DTEND:20140225T163500Z
UID:TALK51074@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Co-authors: J.H. Lopez (Syracuse University)\, J.M. Schawarz (
 Syracuse University)\, M. Lisa Manning (Syracuse University)\n\nRecent obs
 ervations demonstrate that densely packed tissues exhibit features of glas
 sy dynamics\, such as caging behavior and dynamical heterogeneities\, alth
 ough it has remained unclear how single-cell properties control this behav
 ior. Here we develop numerical and theoretical models to calculate energy 
 barriers to cell rearrangements using Surface Evolver\, which help govern 
 cell migration in cell monolayers. In contrast to work on sheared foams\, 
 we find that energy barrier heights are exponentially distributed and depe
 nd systematically on the cell's number of neighbors. Based on these result
 s\, we predict glassy two-time correlation functions for cell motion\, wit
 h a timescale that increases rapidly as cell activity decreases. These cor
 relation functions are used to construct simple random walks that reproduc
 e the caging behavior observed for cell trajectories in experiments. This 
 work provides a theoretical framework for predicting collective motion of 
 cells in wound-heali ng\, embryogenesis and cancer tumorigenesis. \n\nRela
 ted Links: http://arxiv.org/abs/1308.3891 - Preprint\n
LOCATION:Seminar Room 1\, Newton Institute
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