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CATEGORIES:Cambridge Infectious Diseases
SUMMARY:Type VI Secretion System: structure\, function and
  dynamics of a multicomponent nanomachine that is 
 evolutionarily related to a contractile phage tail
   - Marek Basler\, University of Basel 
DTSTART;TZID=Europe/London:20140226T161500
DTEND;TZID=Europe/London:20140226T171500
UID:TALK50974AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/50974
DESCRIPTION:Secretion systems allow bacteria to transport macr
 omolecules such as proteins into host cells during
  pathogenesis or bacterial cells during competitio
 n in various ecological settings. Type VI Secretio
 n Systems (T6SS) are encoded by a cluster of 15-20
  genes that is present in at least one copy in app
 roximately 25% of all sequenced Gram-negative bact
 eria. Several T6SS components are structural homol
 ogs of components of a contractile bacteriophage t
 ail and assemble into a large structure that can b
 e studied using whole cell electron cryo tomograph
 y and live cell fluorescence microscopy. A combina
 tion of these techniques allows to obtain high res
 olution structure of T6SS in situ and to follow T6
 SS assembly in time. This provides an unprecedente
 d level of understanding of this dynamic nanomachi
 ne. I will discuss structure\, function and dynami
 cs of T6SS in various model organisms as well as a
  mechanism of T6SS activation and substrate delive
 ry. \n
LOCATION:Max Perutz Lecture Theatre\, MRC LMB
CONTACT:Anna Davies
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