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SUMMARY:Kinetics and Pathways in Self-Assembly: Light Scattering and Theor
 etical Studies on Human Papillomavirus Capsids - Professor David Wu\,  Che
 mical Engineering Department\,  Colorado School of Mines
DTSTART:20060609T131500Z
DTEND:20060609T141500Z
UID:TALK4993@talks.cam.ac.uk
CONTACT:vh233
DESCRIPTION:Viral self-assembly is an archetype of self-assembly from a fe
 w relatively simple subunits into a complex functional structure.  Althoug
 h extraordinary progress has been made in determining the structure of ico
 sahedral viruses\, relatively little is known about the mechanisms of asse
 mbly.  Such knowledge is important not only for biological understanding o
 f viruses\, and potential therapeutic exploitation\, but also for general 
 insights into the control of self-assembly.  We have measured capsid growt
 h by multi-angle laser light scattering and identified points of kinetic c
 ontrol within a single-pathway model due to Zlotnick.  Using stochastic si
 mulations of model assembly systems\, we have demonstrated that off-pathwa
 y assembly and error-correction can qualitatively change the rate and fide
 lity of self-assembly.
LOCATION:IRC in Superconductivity Seminar Room\, Cavendish Laboratory
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