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SUMMARY:Brain Maturation and the Emergence of Depressive Symptoms: Evidenc
 e from Neuroimaging - Prof. John Suckling\, Department of Psychiatry\, Uni
 versity of Cambridge
DTSTART:20131114T123000Z
DTEND:20131114T133000Z
UID:TALK48543@talks.cam.ac.uk
CONTACT:Dr Robert Dudas
DESCRIPTION:Along with many other scientific fields\, psychiatry - and neu
 roscience more\ngenerally - has been transformed by the digital revolution
 . Brain imaging\nnow has a central role in the development of our understa
 nding in\npsychophysiological processes that are widely accepted as formin
 g the\nbiological substrate for clinical phenotypes. Major Depressive Diso
 rder\n(MDD) in adult populations is now well characterised in terms of bra
 in\nstructure and function from quantitative meta-analyses of the extant\n
 literature\, with varying degrees of support for current neurobiological\n
 models.\n\nMR-IMPACT is a Medical Research Council funded adjunctive study
  to the\nIMPACT (improving mood with psychoanalytic therapy or cognitive b
 ehaviour\ntherapy) clinical trial. Whilst post-treatment follow-up assessm
 ents are\nongoing\, baseline (pre-treatment) data are available for 128 pa
 tients (aged\n12-17 years) and 40 matched control participants. Assessment
 s include\nmagnetic resonance imaging (MRI) of anatomy\, functional MRI du
 ring tasks\nsensitive to affective bias in memory\, response inhibition an
 d facial\nprocessing as well as during task-absent (i.e. rest) conditions.
 \n\nPreliminary results indicate some main effects of brain connectivity\,
  but\nalso that the trajectories during adolescence of brain structure and
 \nfunction\, as well as cognition\, are altered in MDD. Bearing in mind th
 e \nstrong prior literature on the importance of early years experiences t
 o the\nprevalence of MDD in later life\, and the well established brain ch
 anges\nassociated with MDD in adulthood\, the emergence of depressive symp
 toms\nduring the second decade of life appears to be mediated by altered\n
 trajectories off brain maturation kindled by pre-existing vulnerabilities.
LOCATION:Herchel Smith Building\, Addenbrooke's Site
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