BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:microRNAs\, circular RNAs\, and micropeptides - Professor Nikolaus
  Rajewsky\, Max Delbrück Center for Molecular Medicine\, Berlin
DTSTART:20140324T150000Z
DTEND:20140324T161500Z
UID:TALK46283@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:We and others have recently identified tens of thousands of ci
 rcular RNAs (circRNAs) in animal cells. Their extraordinary stability and 
 differential expression makes them interesting biomarker candidates. I wil
 l update on our efforts to trace circRNA expression across tissues and evo
 lution\, and our attempts to understand more about biogenesis and possible
  function of circRNAs. \n\nI will then discuss our attempts to identify fu
 nctional "micropeptides"\, small ORFs which until very recently have escap
 ed genome annotation efforts. Our data argue that numerous so-called long-
 noncoding RNAs ("lincRNAs") in fact encode small\, functionally important 
 micropeptides.\n\nFinally I will present a method that allows us to bioche
 mically map tens of thousands of miRNA:target RNA duplexes context-depende
 nt and in vivo. These data enabled us to get new insights into principles 
 of miRNA target recognition.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
END:VEVENT
END:VCALENDAR