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SUMMARY:Vascularization patterns and fluid flow in growing tumours - Riege
 r\, H (Universitt des Saarlandes)
DTSTART:20130628T134500Z
DTEND:20130628T143000Z
UID:TALK45965@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Growing tumours remodel the vascular network by generating new
  blood vessels (angiogensis)\, by co-opting already existing ones and by v
 essel regression. We want to understand the physical determinants of the e
 merging tumour vascularization patterns and the characteristics of the res
 uting blood and interstitial fluid flow. For this purpose we develop a the
 oretical model combining a dynamically evolving and blood flow carrying pi
 pe network with a non-liear growth process\, intercommunicating via nutrie
 nt and growth factor fields. With it we discuss mechanisms leading to tumo
 r compartmentalization\, hot spot formation\, and interstitial fluid flow 
 patterns impeding drug delivery.\n\n
LOCATION:Seminar Room 1\, Newton Institute
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