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SUMMARY:A continuum model of epithelial spreading - Koepf\, M (Technion - 
 Israel Institute of Technology)
DTSTART:20130624T130000Z
DTEND:20130624T133000Z
UID:TALK45858@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:We present a continuum model of unconstrained epithelial sprea
 ding. The tissue is described as a polarizable and chemo-mechanically inte
 racting layer with neo-Hookean elasticity. Our model reproduces the sponta
 neous formation of finger-like protrusions commonly observed in experiment
 . Statistics of velocity orientation obtained from numerical simulation sh
 ow strong alignment in the fingers opposed to an isotropic distribution in
  the bulk\, as has been measured by Reffay et al. (Reffay et al.\, Biophys
 ical Journal\, 2011). The results faithfully reproduce faster relative adv
 ance of cells close to the leading edge of the tissue\, as well as spatial
  velocity correlations and stress accumulation within the tissue\, which p
 roceeds in form of a "mechanical wave"\, traveling from the wound edge inw
 ards (cf. Serra-Picamal et al.\, Nature Physics\, 2012). \n\nM H Koepf\, L
  M Pismen: A continuum model of epithelial spreading (2013) submitted \n\n
 M H Koepf\, L M Pismen: Non-equilibrium patterns in polarizable active lay
 ers (2013) submitted\n\nCo-author: Leonid M. Pismen (Department of Chemica
 l Engineering\, Technion - Israel Institute of Technology\, 32000 Haifa\, 
 Israel) \n\n
LOCATION:Seminar Room 1\, Newton Institute
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