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SUMMARY:Direct Selection for Antibodies that Control Cell Fates from Intra
 cellular Combinatorial Antibody Libraries   - Professor Richard Lerner\, T
 he Scripps Research Institute\, USA
DTSTART:20130605T110000Z
DTEND:20130605T120000Z
UID:TALK45660@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:In this talk we will describe the use of combinatorial antibod
 y libraries to endow cells with new binding energy landscapes for the purp
 ose of regulating their phenotypes. Antibodies that are expressed in cells
  infected with a lentiviral combinatorial antibody library are selected di
 rectly for function rather than only for binding. Many different agonist a
 ntibodies were selected using this method including TPO\, EPO\, G-CSF\, in
 tegrin\, and neurogenesis phenocopies.. The most powerful format is an aut
 ocrine based selection system.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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