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CATEGORIES:Engineering - Mechanics and Materials Seminar Seri
 es
SUMMARY:MR imaging and biomechanical analysis: the assessm
 ent of carotid atherosclerotic plaque vulnerabilit
 y - Dr Zhongzhao Teng\,  University Department of 
 Radiology\, University of Cambridge
DTSTART;TZID=Europe/London:20130531T140000
DTEND;TZID=Europe/London:20130531T150000
UID:TALK45005AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/45005
DESCRIPTION:Stroke is the third leading cause of death in the 
 developed countries and the most common cause of l
 ong term disability.  Carotid artery atherosclerot
 ic disease is the predominant precipitant of ischa
 emic events. Conventionally\, angiography is used 
 for the clinical assessment. However\, angiography
  identifies only those lesions that encroach signi
 ficantly into the lumen\, and there is a poor corr
 elation between the angiographic appearance of pla
 ques and subsequent risk of plaque rupture. Effort
 s from the past 30 years indicate that atheroscler
 otic plaque vulnerability has a close relationship
  with certain morphological features\, including f
 ibrous cap thickness\, size of lipid-rich necrotic
  core\, presence of haemorrhage and luminal contou
 rs. Moreover\, recent results indicate that critic
 al mechanical conditions are additional driving fa
 ctors in plaque rupture\, when plaque loading exce
 eds material strength.\n\nAccordingly this talk wi
 ll focus on: (1) characterisation of morphology an
 d compositional features in atherosclerotic plaque
  and its relationship with subsequent clinical eve
 nts using in-vivo magnetic resonance (MR) imaging\
 ; (2) medical image-based mechanical analysis to s
 eek new non-invasive bio-markers for plaque vulner
 ability assessment\; and (3) the pathological impa
 ct of critical mechanical conditions within the pl
 aque structure.
LOCATION:Oatley Seminar Room\, Department of Engineering
CONTACT:Ms Helen Gardner
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