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SUMMARY:Global microRNA level regulation of EGFR-driven cell-cycle protein
  network in breast cancer - Stefan Wiemann (DKFZ Heidelberg)
DTSTART:20130625T160000Z
DTEND:20130625T170000Z
UID:TALK44879@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:The EGFR-driven cell-cycle pathway has been extensively studie
 d also because of its role in cancer. While several studies reported regul
 ation of individual pathway components by microRNAs (miRNAs)\, we were out
  to study how miRNAs modulate the EGFR protein network at a global level. 
 A large-scale miRNA screening approach was combined with a quantitative ta
 rgeted proteomics readout to uncover potential regulatory modules. Network
 -analysis revealed miRNAs simultaneously co-regulating several proteins th
 at act in the same functional modules. There\, miR-124\, miR-147 and miR-1
 93a-3p co-target EGFR-driven cell-cycle network proteins and inhibit cell-
 cycle progression and proliferation in our breast cancer model system. Fut
 ure work will embark on the tools generated during this screen and investi
 gate the impact of the tested miRNAs on other\, metastasis-relevant pathwa
 ys. This shall help to generate a comprehensive map of the miRNA/pathway i
 nteraction network\, and form the basis for experimental testing of combin
 atorial perturbations in the network aimed at abrogating cancer phenotypes
 .\n
LOCATION:Cancer Research UK Cambridge Institute\, Room 009
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