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SUMMARY:Epigenetic regulation of tissue growth in Drosophila. - Dr Anne Ka
 thrin Classen\, LMU Munich 
DTSTART:20130523T133000Z
DTEND:20130523T143000Z
UID:TALK44447@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Research in our group investigates cellular mechanisms of epig
 enetic plasticity. We aim to understand:\n\n1) how epigenetic plasticity i
 s regulated by signaling pathways\,\n\n2) how epigenetic switches modulate
  gene expression\,\n\n3) how these processes causes the emergence of cell 
 and tissue behavior.\n\nOur lab is applying the advantages of the Drosophi
 la system – sophisticated genetic tools\, cellular analysis and experime
 ntal tractability – to dissect these three questions in fly models of de
 velopment\, tumorigenesis and tissue regeneration. The function and regula
 tion of the conserved epigenetic regulators of the Polycomb and Trithorax 
 group complexes (PcG/TrxG) in these contexts is currently our main focus.\
 n\nWe are using a range of molecular\, cell-biological and biochemical app
 roaches\, such as Confocal Microscopy\, DamID profiling and Mass Spectrome
 try to bridge molecular epigenetics with in vivo developmental cell biolog
 y. We hope to contribute to the understanding of basic epigenetic processe
 s that function during embryonic development\, but also in contexts of cel
 lular stress and injury that are caused\, for example\, by chronic disease
 s or ageing.
LOCATION:Part II Room\, Department of Genetics
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