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SUMMARY:Investigating temperature signalling pathways in Arabidopsis thali
 ana and Saccharomyces cerevisiae - David Schoepfer
DTSTART:20130517T113000Z
DTEND:20130517T120000Z
UID:TALK44293@talks.cam.ac.uk
CONTACT:Megan Cooper
DESCRIPTION:Plants are highly sensitive to ambient temperature and can mod
 ify their growth and development in response to changes as small as 1˚C. 
 In the model plant Arabidopsis thaliana\, hundreds of genes undergo transc
 riptional reprogramming within minutes of exposure to heat\, a process reg
 ulated in part by heat-shock factors. The Wigge laboratory has demonstrate
 d that transcriptional regulation of temperature responses involves change
 s in occupancy of the histone variant H2A.Z\, though the means by which th
 is chromatin alteration occurs is unknown. Despite considerable efforts to
  identify temperature sensors in plants\, the primary mechanism of tempera
 ture perception remains to be discovered. In parallel to an on-going forwa
 rd genetic screen being conducted by the Wigge laboratory\, I am using a c
 hemical genomics approach to identify proteins required for temperature si
 gnalling in A. thaliana. In order to gain a better understanding of the ro
 le of H2A.Z in the heat-shock response\, I am investigating post-translati
 onal modifications of H2A.Z and the interplay between H2A.Z-containing nuc
 leosomes and stress-associated transcription factors in Saccharomyces cere
 visiae. As well as identifying key components of temperature signalling pa
 thways in plants\, this project could potentially identify chemicals with 
 useful agricultural applications\, such as thermal protection of plant rep
 roduction.
LOCATION:Biffen Lecture Theater\, Department of Genetics
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