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CATEGORIES:Foster Talks
SUMMARY:Food for thought: nutrients and neural stem cells 
 in Drosophila - Dr Alex Gould. MRC National Instit
 ute for Medical Research\, London.
DTSTART;TZID=Europe/London:20130214T160000
DTEND;TZID=Europe/London:20130214T170000
UID:TALK40890AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/40890
DESCRIPTION:Moderate nutrient deprivation in animals is often 
 compatible with development\, albeit into an under
 sized adult. One important survival strategy here 
 is to spare the growth of certain critical organs\
 , such as the CNS\, at the expense of others. For 
 example\, in humans\, fetal nutrient restriction c
 an result in asymmetric intrauterine growth restri
 ction (IUGR)\, characterised by undersized neonate
 s with relatively large brains. We have been explo
 ring the molecular mechanisms underlying this type
  of brain sparing in the context of the growing CN
 S of Drosophila. This work has identified a highly
  modified Insulin/Tor signalling network that perm
 its neural stem cells to grow and divide at the no
 rmal rate under conditions of nutrient restriction
  that are severe enough to shut down all net growt
 h of the body. We also find that optimal CNS growt
 h during this type of nutrient stress requires neu
 ral stem cells to be metabolically coupled to thei
 r glial-cell niche. The possible relevance of thes
 e findings to mammalian brain sparing and\, more g
 enerally\, to the mechanisms by which nutrients re
 gulate the relative growth of different tissues wi
 ll be discussed.\n\nSelected Publications (last fi
 ve years)\nSteinhauser\, M.L\, Bailey\, A.P\, Seny
 o\, S.E\, Guillermier\, C\, Perlstein\, T.S\, Goul
 d\, A.P\, Lee\, R.T and Lechene\, C.P. (2012). Mul
 ti-isotope imaging mass spectrometry quantifies st
 em cell division and metabolism.\nNature 481\, 516
 -519\nCheng\, L.\, Bailey\, A.\, Leevers\, S.\, Ra
 gan\, T.\, Driscoll\, P. and Gould\, A.P. (2011). 
 Anaplastic Lymphoma Kinase Spares Organ Growth dur
 ing Nutrient Restriction in Drosophila.\nCell 146\
 , 435-447.\nSousa-Nunes\, R\, Yee\, LL and Gould\,
  A.P. (2011). Fat cells reactivate quiescent neuro
 blasts via TOR and glial insulin relays in Drosoph
 ila.\nNature 471\, 508-512.\nMaurange\, C.\, Cheng
 \, L.\, and Gould\, A.P. (2008). Temporal transcri
 ption factors and their targets schedule the end o
 f neural proliferation in Drosophila.\nCell 133\, 
 891-902.\nMiguel-Aliaga\, I.\, Thor\, S.\, and Gou
 ld\, A.P. (2008). Postmitotic specification of Dro
 sophila insulinergic neurons from pioneer neurons.
 \nPLoS Biology 6\, e58.\nGutierrez\, E.\, Wiggins\
 , D.\, Fielding\, B. and Gould\, A.P. (2007) Speci
 alized hepatocyte-like cells regulate Drosophila l
 ipid metabolism.\nNature 445\, 275-280.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\
 , Downing Site
CONTACT:Annabel Griffiths
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