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CATEGORIES:CUED Control Group Seminars
SUMMARY:Estimation\, Identification and control of cell po
 pulations - Professor John Lygeros (Head of the Au
 tomatic Control Laboratory\, ETH Zurich)
DTSTART;TZID=Europe/London:20120507T140000
DTEND;TZID=Europe/London:20120507T150000
UID:TALK37866AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/37866
DESCRIPTION:The talk will discuss the use of stochastic models
  in the molecular biology of populations of cells.
  The starting point will be standard models of che
 mical reaction systems based on the Chemical Maste
 r Equation and its variants such as the moment equ
 ations\; in our context the predictions of these e
 quations will be interpreted as statistics of mole
 cule counts across different cells in the populati
 on. We will first concentrate on state estimation 
 based on single cell measurements\, obtained for e
 xample by flow cytometry. We will also discuss how
  the same filtering method can be used "in silico"
 \, to speed up stochastic simulation by filtering 
 its results through the moment equations. We will 
 then turn to system identification\, in particular
  the estimation of extrinsic noise arising out of 
 reaction rate variability. Finally\, we will discu
 ss control of the statistics of cell populations u
 sing external\, macroscopic control signals\, spec
 ifically light activated gene transcription. The t
 heoretical discussion will be complemented by expe
 rimental results in yeast.
LOCATION:Cambridge University Engineering Department\, LR5
CONTACT:Dr Jason Z JIANG
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