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SUMMARY:Ubiquitin flips the anaphase switch - David Morgan\, UCSF
DTSTART:20120413T151500Z
DTEND:20120413T170000Z
UID:TALK37239@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Chromosome segregation in anaphase of mitosis is triggered by 
 a giant ubiquitin ligase called the Anaphase-Promoting Complex or cyclosom
 e (APC). We are studying the biochemical mechanisms by which the APC binds
  its substrates and modifies them processively with polyubiquitin chains. 
 Our recent work has focused on the mechanisms that inhibit APC activity wh
 en defects in the mitotic spindle delay the onset of anaphase.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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