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SUMMARY:Models of the antibody response to malaria infection and vaccinati
 on in African children - Michael White\, Imperial
DTSTART:20111121T113000Z
DTEND:20111121T123000Z
UID:TALK33680@talks.cam.ac.uk
CONTACT:Prof. Julia Gog
DESCRIPTION:Children in regions of intense malaria transmission are partic
 ularly vulnerable to malaria in their first years of life before they acqu
 ire substantial immunity. The processes underlying the acquisition and los
 s of immunity are investigated with biological models of immunological pro
 cesses fitted to antibody titres to malaria parasite antigens using data f
 rom longitudinal cohort studies of Ghanaian and Gambian children.\n \nRece
 nt Phase III trials of the RTS\,S malaria vaccine have demonstrated 55% ef
 ficacy against clinical malaria in African children. Models are use to exp
 lore the potential impact of vaccination on naturally-acquired immunity an
 d incidence of clinical malaria\, in a range of transmission settings and 
 against a background of existing malaria control interventions such as ins
 ecticide treated nets.
LOCATION:DD47\, Cripps Court\, Queens' College
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