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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Jointly optimal design of Phase II and Phase III c
 linical trials: an over-arching approach - Jenniso
 n\, C (Bath)
DTSTART;TZID=Europe/London:20110816T103000
DTEND;TZID=Europe/London:20110816T110000
UID:TALK32377AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/32377
DESCRIPTION:We consider the joint design of Phase II and Phase
  III trials. We propose a decision theoretic formu
 lation with a gain function arising from a positiv
 e Phase III outcome and costs for sampling and for
  time taken to reach a positive conclusion. With a
  prior for the dose response model and a risk curv
 e for the probability that doses fail on safety gr
 ounds\, the challenge is to optimise the design fo
 r comparing doses in Phase II\, the choice of dose
  or doses to take forward to Phase III\, and the P
 hase III design. We shall show it is computational
 ly feasible to tackle this problem and discuss pos
 sible generalisations from an initial\, simple for
 mulation.\n
LOCATION:Seminar Room 1\, Newton Institute
CONTACT:Mustapha Amrani
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