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SUMMARY:Phylodynamic inference - accounting for the interaction of evoluti
 onary and ecological processes - Khnert\, D (Auckland)
DTSTART:20110622T094000Z
DTEND:20110622T100000Z
UID:TALK31881@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Rapidly evolving viruses such as HIV\, HCV and Influenza virus
  are of major interest in phylogenetics. They are special in that their ec
 ological and evolutionary processes act on the same timescale and are ther
 efore entangled. The cross-reaction of the two processes must be accounted
  for when inferring epidemiological parameters and/or phylogenetic history
 . \n\nOur aim is a joint epidemiological phylogenetic\, i.e. phylodynamic\
 , analysis of genomic data by incorporating the dynamics of an SIR model i
 nto Bayesian phylogenetic inference. A new version of the birth-death mode
 l (Stadler\, 2010) that incorporates sampling-through-time and can also be
  extended to allow birth and death rates to change over time can be parame
 terized to facilitate modeling SIR-like population dynamics while reconstr
 ucting phylogenetic history and simultaneously estimating epidemiological 
 parameters. \n\nReferences Stadler\, T.\, 2010. Sampling-through-time in b
 irth-death trees. Journal of Theoretical Biology. \n
LOCATION:Seminar Room 1\, Newton Institute
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